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hope cair (community arts integrated research)



plurality series by pauline sameshima & tashya orasi

pictureseries title: plurality six 24 x 24 aluminum prints
​these artworks are a part of a $26.5 us million funded national institutes of health project called hope: hiv obstruction by programmed epigenetics. 

hope is one of ten martin delaney collaboratories funded by the national institutes of health (nih) to develop cures for hiv. hope includes 16 institutions around the world, three pharmaceutical companies and various community partnerships.

the mission of the hope collaboratory is to find a cure for hiv using a novel “block-lock-excise” (ble) approach—that entails the long-term durable silencing of viral expression towards permanent excision of the latent virus and control of virus infection in the absence of therapy. 

these investigations by sameshima and orasi seek to understand the science of block-lock-excise. as educators, they use the arts to theorize and respond to interpretations of the science of ble and relational and community responses to ble.


the wire artworks in the trees share how latent viruses might be integrated into human dna. the polymer clay artworks investigate metaphors for understanding the science of ble. 

​their vision, as part of the hope cair team, is to transcend disciplines and integrate community voices in innovative ways. the created art can tell scientists how scientific cures are perceived and how the cures may be taken up by the community. 

​​from left to right:
chromosome territories, pauline sameshima, wire & bead
cell mates, pauline sameshima, polymer clay
acceptance, tashya orasi, polymer clay 
chromosome territories, pauline sameshima, wire & bead
one cell one world, pauline sameshima, polymer clay
becoming, tashya orasi, wire, chainmail & bead
block lock excise video by the hope cair team
picturethe hope cair team includes members from the united states, brazil and canada. members from 阿根廷vs墨西哥竞猜 (from left to right): dr. pauline sameshima, emma wurdemann-stam, colin kutchyera and tashya orasi. 2023.



the animated video, narrated by raif derrazi, was released by the hope community advisory board that explains the block-lock-excise approach to finding an hiv cure. 'hiv obstruction by programmed epigenetics,' or hope. this video explains how scientists are investigating a novel approach to cure hiv called “block-lock-excise.” the video is a result of active engagement with communities to increase awareness around hiv research, cure approaches, and to understand community concerns around treatment and curative medicine. while effective hiv treatments have existed for some time and allowed people living with the disease to live seemingly healthy lives, the absence of a cure means that these individuals still live with increased risks of severe health outcomes and complications.

this short animation, led by dr. vivian avelino-silva, translates hope’s strategy for developing a cure for hiv into a lay and captivating language based on concerns and discoveries within the community. “effective communication between scientists and community members is crucial for the successful advancement of research. however, scientists and community members often speak distinct languages, segregating players who could be acting cooperatively. the scientific language may sound accurate and compelling to scientific ears, but it might seem intimidating or even untrustworthy to non-specialists,” notes avelino-silva. “this communication challenge is commonly encountered in medicine.”

the video is one of many ways that the hope team aims to break this challenge, by combining the science of “block-lock-excise” with input from the community, infused with artistic talent of hope team members. the hope team is guided by an equitable space model design. the community engagement team offers education and hope to non-scientific communities as well as feedback to the scientists through a variety of pathways including art-making workshops, generative hiv art discussions, community interviews with scientists, interactive live instagram and youtube videos, educational animations, and academic publications.


more information and updates about hope cair (community arts integrated research) can be found here.

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