synthetic studies on chaksine

dc.contributor.advisor	orr, d.
dc.contributor.author	evans, john bruce
dc.date.accessioned	2017-06-06t13:08:34z
dc.date.available	2017-06-06t13:08:34z
dc.date.created	1970
dc.date.issued	1970
dc.identifier.uri	http://knowledgecommons.lakeheadu.ca/handle/2453/2203
dc.description.abstract	this thesis is concerned with the preliminary studies in the synthesis of a monoterpenoid alkaloid, chaksine. diethyl methylmalonate was alkylated with 1,3-dibromo propane to give 2-(3-bromopropyl)-2-methylmalonate. hydrolysis and decarboxylation of this product gave the mono acid which was then converted to the corresponding ethyl ester. reduction with lithium borohydride yielded the primary alcohol to which a tetrahydropyran protective group was added. alkylation with diethyl malonate followed by acylation with the mixed anhydride of isovaleric acid and carbobenzyloxyglycine gave diethyl (see document for formula).
dc.language.iso	en_us
dc.subject	alkaloids synthesis
dc.subject	chaksine
dc.title	synthetic studies on chaksine
dc.type	thesis
etd.degree.name	master of science
etd.degree.level	master
etd.degree.discipline	chemistry
etd.degree.grantor	阿根廷vs墨西哥竞猜