dod scleroderma research program announcement

how to apply: 

the fy21 defense appropriations act provides funding to the department of defense scleroderma research program (srp) to support innovative, high-impact scleroderma research. the managing agent for the anticipated program announcements/funding opportunities is the congressionally directed medical research programs (cdmrp) at the u.s. army medical research and development command (usamrdc).

 

the fy21 srp program announcements and general application instructions for the following award mechanisms are posted on the grants.gov website.    

 

applications submitted to the fy21 srp idea development award must address one or more of the following focus areas:

  • define biomarkers (‘omics and/or molecular markers, cell subsets, imaging, patient-reported outcomes) that help inform therapeutic choices (immunosuppressive/anti-fibrotic) or predict course (morbidity) and quality of life.
  • utilize systems biology, multi-omics and preclinical screening approaches (including but not limited to high-throughput screens, the development of animal models, three-dimensional [3d] tissue culture and/or organoids) with the intent to develop drug testing models in order to understand the heterogeneity of disease as well as to develop prevention and therapeutic interventions.
  • studies of diverse populations to include the development of cohorts and identification of potential measures of patient outcomes.

○       understand the unique burden of disease in diverse populations.

  • define functional role of epigenetic changes, multiple cell types, and molecules that mediate pathogenesis and/or initiate or propagate organ-specific disease activity using preclinical models and clinical samples.
  • develop and validate short- and long-term organ-specific and composite clinical outcomes measures to determine treatment efficacy.

○       develop better quantifiable and reproducible measures to assess clinical manifestations including skin, heart, raynaud phenomenon, calcinosis cutis, or gastrointestinal tract morbidity in scleroderma.

○       validate patient-reported outcome measurements to aid in the approval of drug and therapies.

○       develop and validate intermediate biological/surrogate endpoints to support larger clinical proof-of-concept/proof-of-mechanism trials.

 

applications submitted to the fy21 srp translational partnership research award must address one or more of the following focus areas:

  • define biomarkers (‘omics and/or molecular markers, cell subsets, imaging, patient-reported outcomes) that help inform therapeutic choices (immunosuppressive/anti-fibrotic) or predict course (morbidity) and quality of life.
  • utilize systems biology, multi-omics and preclinical screening approaches (including but not limited to high-throughput screens, the development of animal models, 3d tissue culture and/or organoids) with the intent to develop drug testing models in order to understand the heterogeneity of disease as well as to develop prevention and therapeutic interventions.
  • studies of diverse populations to include the development of cohorts and identification of potential measures of patient outcomes.

○       understand the unique burden of disease in diverse populations.

  • define functional role of epigenetic changes, multiple cell types, and molecules that mediate pathogenesis and/or initiate or propagate organ-specific disease activity using preclinical models and clinical samples.
  • conduct population-based or cohort studies to understand the prevalence, heterogeneity, and course of this disease, its manifestations, and its impact on health outcomes and activities for daily living.

○       understanding the unique burden of disease in disease in diverse populations.

○       understand disease heterogeneity (course of disease, prevalence, and associated factors).

○       utilize disease registries linked to biological samples and high-quality clinical data and patient-reported outcomes.

○       conduct fine phenotyping of clinical subsets to address heterogeneity.

  • understand and improve the impact of disease and its treatment on the patient’s experience and quality of life.

○       develop interventions to improve coping with disease.

○       identify main concerns of patients to inform development and validation of patient-reported outcomes.

○       identify interventions that improve quality of life.

○       understand the link between molecule, laboratory, and clinical measures and the patient’s quality of life.

  • develop and validate short- and long-term organ-specific and composite clinical outcomes measures to determine treatment efficacy.

○       develop better quantifiable and reproducible measures to assess clinical manifestations including skin, heart, raynaud phenomenon, calcinosis cutis, or gastrointestinal tract morbidity in scleroderma.

○       validate patient-reported outcome measurements to aid in the approval of drug and therapies.

○       develop and validate intermediate biological/surrogate endpoints to support larger clinical proof-of-concept/proof-of-mechanism trials.

https://cdmrp.army.mil/funding/srp

 

idea development award – letter of intent due august 11, 2021

independent investigators at all academic levels (or equivalent).

new investigators:

• terminal degree must be within the last 10 years.

• must not have received national institutes of health r01 funding.

• must not have received a new investigator award previously from any program within the cdmrp.

• supports conceptually innovative, high-risk/high-reward research that could lead to critical discoveries in

scleroderma research and/or improvements in patient care.

• innovation and impact are important aspects of the award.

• research must address at least one of the srp fy21 idea development award focus areas.

• preliminary data are required and need not be from the scleroderma research field.

• clinical trials are not allowed.

• new investigator collaboration option: supports the continued development of promising independent

investigators that are early in their faculty appointment through collaboration with an established scleroderma

investigator. the initiating principal investigator must be the new investigator

the maximum allowable funding for the entire period of performance is $300,000 for direct costs.

new investigator collaboration option:

• the maximum allowable funding for the entire period of performance is $450,000 for direct costs.

• at least fifty percent of the funding must be allocated to the new investigator.

• indirect costs may be proposed in accordance with the institution’s negotiated rate agreement.

• the maximum period of performance is years.

 

 

translational research partnership award – letter of intent due august 11, 2021

clinicians must be an m.d., d.o. or equivalent with clinical duties and/or responsibilities.

  • at least one member of the partnership must have experience in either scleroderma research or scleroderma patient care as demonstrated by active funding and/or recent publications.
  • supports partnerships between clinicians, research scientists and/or other disciplines that accelerate the movement of promising ideas in scleroderma research into clinical applications. at least one partner must be a clinician.

•        preliminary data are required but need not be from the scleroderma research field.

•        clinical trials are not allowed.

 

a pre-application is required and must be submitted through the electronic biomedical research application portal (ebrap) at https://ebrap.org prior to the pre-application deadline.  all applications must conform to the final program announcements and general application instructions available for electronic downloading from the grants.gov website.  the application package containing the required forms for each award mechanism will also be found on grants.gov.  a listing of all cdmrp and other usamrdc extramural funding opportunities can be obtained on the grants.gov website by performing a basic search using cfda number 12.420. 

 

for email notification when program announcements are released, subscribe to program-specific news and updates under “email subscriptions” on the ebrap homepage at https://ebrap.org.  for more information about the srp or other cdmrp-administered programs, please visit the cdmrp website (https://cdmrp.army.mil).

 

point of contact:

cdmrp help desk

301-682-5507
help@ebrap.org

external deadline: 
wednesday, august 11, 2021
funding source: 
external
funding level: 
research

alfred heineken fondsen foundation

canada healthy communities initiative

how to apply: 

public spaces are the glue to our communities: they enable a feeling of belonging, of social cohesion and encourage our sense of collective identity. covid-19 has seriously constrained our access and use of these spaces in communities across canada. impacts of the virus have also been extraordinarily uneven, underscoring inequalities across communities and disproportionately impacting those who are already experiencing vulnerability as a result of systemic inequalities. 

in the face of these challenges, communities have been extraordinarily resourceful and resilient in improvising temporary and longer-lasting solutions to the challenges of covid-19. many are undertaking work for immediate needs but also thinking about how to build pandemic-resilient spaces for the future. we are seeing new digital solutions, that allow people and communities to feel connected, safe and healthy all while respecting public health measures and norms such as physical distancing and mask-wearing.

the healthy communities initiative will provide funding to a broad range of organizations, including local governments, charities, indigenous communities and nonprofits, for projects, programming and services that help communities : 

create safe and vibrant public spaces

improve mobility options

provide innovative digital solutions

external deadline: 
friday, june 25, 2021
funding source: 
external
funding level: 
research

community foundations of canada

request for proposals – heqco skills consortium

how to apply: 

the purpose of this rfp is to select education and training providers to join a newly established heqco skills consortium. the skills consortium will evaluate programs or interventions relating to the acquisition, development and/or articulation of transferable skills. specifically, we seek partners that are prepared to:

1) build upon heqco‘s skills research by using an assessment tool that is proven to be valid and reliable, and/or another established methodology, to measure change over time in either (1) student skills or (2) 世界杯2022赛程表淘汰赛 ‘ ability to articulate skills as a result of an innovative educational program or targeted intervention.
2) commit to sharing best practices with other members of the consortium through bi-annual meetings and an annual deliverable; and
3) participate actively in various knowledge mobilization strategies, such as presenting at conferences, participating in webinars or writing blog posts, to share their approaches and learnings with other members of the consortium as well as the broader postsecondary community.
programs and interventions are not required to be new, and assessment tools / methods are not limited to those that heqco has used in previous projects

external deadline: 
monday, june 14, 2021
funding source: 
external
funding level: 
research

investigators in the pathogenesis of infectious disease (path) award

how to apply: 

the investigators in the pathogenesis of infectious disease (path) award provides $500,000 over five years to support accomplished investigators at the assistant professor level to study pathogenesis, with a focus on the interplay between human and microbial biology, shedding light on how human and microbial systems are affected by their encounters.

external deadline: 
friday, july 16, 2021
funding source: 
external
funding level: 
research

call for applications: ndrio-portage covid-19 data curation funding

eligibility: 

applications are welcomed from canadian researchers and research programs eligible to administer funding received through ndrio. where applicable, research must be compliant with the tri-council policy statement: ethical conduct for research involving humans – tcps 2 (2018).

this call is not open to federal government institutions, such as federal departments, agencies, crown corporations, and their research facilities.

this funding may be used for the stewardship and curation of research data related to the covid-19 pandemic from any discipline. applications are welcomed from stem and health disciplines as well as from the social sciences, humanities, and arts.

any activities undertaken for the stewardship and curation of data throughout the data lifecycle, by highly-qualified personnel (hqp),[4] may be included in the scope of activities for which funding is requested through this call. generally, any activities covered in portage’s covid-19 rdm guidance will be eligible. this includes activities such as data management planning, curation, de-identification, and deposit in a recommended repository.

how to apply: 

ndrio and portage are pleased to announce the availability of funding to support the curation of canadian research data related to the covid-19 pandemic. the purpose of this funding is to bring covid-19 related data into timely compliance with the fair guiding principles (findable, accessible, interoperable, and reusable) for the management of research data, algorithms, tools and workflows.[1] ultimately, increasing the fairness of datasets makes them discoverable and re-usable by both humans and machines, enabling downstream research. as a secondary objective, this initiative aims to build capacity for research data management (rdm) in canada by supporting the training of highly-qualified personnel (hqp) in data stewardship and curation.

about the covid-19 data curation funding call

this initiative will contribute up to cad $336,000 toward the employment of highly-qualified personnel by eligible applicants for data stewardship and curation activities taking place between the date of the award and march 31, 2022. the maximum funding available per project is cad $42,000. this funding may only be used for the contracting of hqp for the stewardship or curation of data from research related to the covid-19 pandemic. the amount of funding awarded to each recipient will be based on the scope and defined needs of each project as demonstrated through the application process.

additionally, funding recipients will receive support from portage in the form of an initial consultation with the data curation team and with the possibility of group or individual training activities during the course of the project, as determined by the needs of recipients and in consultation with portage.

external deadline: 
friday, may 28, 2021
funding source: 
external
funding level: 
research

new digital research infrastructure organization / portage network

enhanced ontario community environment fund call for proposals

how to apply: 

the ministry of the environment, conservation and parks (mecp) is currently accepting applications for our enhanced ontario community environment fund (ocef). we are specifically looking for projects that focus on the protection and preservation of our land, air and water.

 

as part of our made-in-ontario environment plan commitment to protect our air, land and water, ontario is holding polluters accountable by strengthening the enforcement tools we use to ensure compliance with environmental laws, while taking steps to help communities improve the environment in areas impacted by pollution.

 

our enhanced ontario community environment fund invests money, collected from environmental penalties, back into community-based environmental projects in the region where a violation or environmental impact happened.

 

this year, close to $900,000 is available for projects in four of the five regions identified by the ministry of the environment, conservation and parks regions. please visit the ocef webpage to see if your project proposal would fall within one of the following eligible regions:

  • northern region:  $475,009.52
  • southwest region: $306,151.65
  • eastern region: $62,864.40
  • west-central region: $43,298.00
  • central region : no funding available this round because the value of penalties collected did not meet the minimum funding threshold of $5,000.

the funding available this year (2021) was collected between 2016 and 2019, while the program was temporarily paused. during this period, the ministry considered how the fund could be enhanced in the future, outlined in our proposal to expand the use of administrative monetary penalties to a broader range of environmental violations.

 

not-for-profit organizations, first nations and métis communities, municipalities, schools, colleges, universities and conservation authorities can apply to access these government grants. during the competitive evaluation process, applicants will be required to demonstrate that their projects have a direct benefit to the environment, and support one, or both of the following goals:

  1. increased environmental restoration and remediation activities, that repair environmental harm. project examples may include, but are not limited to:
    1. planting trees, shrubs or plants to help mitigate and adapt to climate change
    2. rebuilding fish habitat and creating fish spawning beds
    3. stabilizing stream banks and creating buffer strips to reduce nutrient run-off
    4. restoring streams to improve habitat and water quality
  2. resilient communities and local solutions to environmental issues. project examples may include, but are not limited to:
    1. improving the resilience of natural ecosystems by restoring wetlands and preserving areas of significant environmental and ecological importance
    2. installing rain gardens to reduce the risk of flooding and help communities adapt to climate change

the deadline to submit an application through the transfer payment ontario portal is june 23rd, 2021 at 5:00 pm. please review the program application guide for guidance on applying to the program. we will notify successful applicants of the result by summer 2021 and projects may begin in fall 2021.

 please note:  projects must include a direct environmental benefit in order to be eligible for funding. projects that focus exclusively on research, education and/or awareness are not eligible.

external deadline: 
wednesday, june 23, 2021
funding source: 
external
funding level: 
research

team grant : heart failure research network

how to apply: 
the purpose of this funding opportunity is to support a single nationally coordinated, interdisciplinary research network (including patients, people with lived/living experience, family/caregivers, indigenous elders or knowledge keepers, government, policy makers, not-for-profit organizations, health care providers, researchers, clinicians and industry) focused on hf across the lifecycle, within various health delivery settings (including hospitals, primary care, home and community care as examples), and must consider hf in the context of multi-morbidity, indigenous health and well-being and health disparities. this national network will bring together experts across canada from different disciplines, different sectors, and different jurisdictions working collaboratively on a number of inter-related research projects under an integrated and unified program of research. the overall goal of the network is to understand the underlying causes, pathophysiology and social determinants of hf and to improve the prevention, detection, management, patient outcomes, quality of life, and delivery of care of this common and multifactorial condition.
 

the specific objectives of this funding opportunity are:

  • improve understanding of the underlying causes, social determinants, pathophysiology, prevention, detection and management of hf and its subtypes (e.g., hfpef), including the context of multi-morbidity, indigenous health and well-being, and health disparities, in canada through coordinated national research activities across the research pillars to co-create new knowledge, including technical and scientific expertise;
  • accelerate the iterative, bi-directional translation of evidence into practices, policies and new models of care for improved prevention and patient treatment, care, experiences, quality of life and outcomes through a collaborative national multi-sectoral, multi-pillar, and interdisciplinary approach;
  • develop, implement, evaluate, and validate interventions and models of care that foster improved hf health care delivery and outcomes; and, accelerate the mobilization of research discoveries and best, promising and wise practices to bridge gaps between research outcomes and health impacts; and,
  • build, foster, and promote relevant research capacity, including training and early career development, by providing high-quality, interdisciplinary training and mentoring through active engagement of established researchers, community leaders, including indigenous elders and knowledge keepers, early career investigators and trainees.
external deadline: 
wednesday, july 7, 2021
funding source: 
external
funding level: 
research

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