date: september 16, 2024

congratulations to anirudh on the successful defense of his msc thesis in physics. anirudh presented his work titled ‘evaluation of multi-angle imaging with planar organ-targeted positron emission tomography detectors‘ conducted under the supervision of dr. alla reznik. the reznik group wishes him all the best as he embarks on his phd studies.

congratulations once again!

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a case report from our group has been published in frontiers in oncology!

abstract: contrast-enhanced breast magnetic resonance imaging (mri) is currently recommended as a screening tool for high-risk women and has been advocated for women with radiologically dense breast tissue. while breast mri is acknowledged for its high sensitivity (with an exception for lower-grade ductal carcinoma in situ (dcis) where emerging techniques like diffusion-weighted imaging offer improvement), its limitations include sensitivity to hormonal changes and a relatively high false-positive rate, potentially leading to overdiagnosis, increased imaging uncertainty, and unnecessary biopsies. these factors can exacerbate patient anxiety and impose additional costs. molecular imaging with breast-targeted positron emission tomography (pet) has shown the capability to detect malignancy independent of breast density and hormonal changes. furthermore, breast-targeted pet has shown higher specificity when compared with mri. however, traditional pet technology is associated with high radiation dose, which can limit its widespread use particularly in repeated studies or for undiagnosed patients. in this case report, we present a clinical application of low-dose breast imaging utilizing a breast-targeted pet camera (radialis pet imager, radialis inc). the case involves a 33-year-old female patient who had multiple enhanced lesions detected on breast mri after surgical removal of a malignant phyllodes tumor from the right breast. a benign core biopsy was obtained from the largest lesion seen in the left breast. one month after the mri, 18f-fluorodeoxyglucose (18f-fdg) pet imaging session was performed using the radialis pet imager. although the radialis pet imager has proven high count sensitivity and the capability to detect breast lesions with low metabolic activity (at a dose similar to mammography), no areas of increased 18f-fdg uptake were visualized in this particular case. the patient underwent a right-sided nipple-sparing mastectomy and left-sided lumpectomy, with bilateral reconstruction. the excised left breast tissue was completely benign, as suggested by both core biopsy and the pet results. the case presented highlights a promising clinical application of low-dose breast-targeted pet imaging to mitigate the uncertainty associated with mri while keeping radiation doses within the safe range typically used in x-ray mammography.

continue reading the article: https://doi.org/10.3389/fonc.2024.1405404

the post new case report: possible role of low-dose pem for avoiding unneeded procedures associated with false-positive or equivocal breast mri results appeared first on rezniklab and posted by pavlo karasyuk.

two fourth-year undergraduate 世界杯2022赛程表淘汰赛 , henry maa-hacquoil and madeline rapley, recently completed successful defences of their honours theses in our lab!

henry’s project focused on exploring different light guide designs to enhance the positioning accuracy of pet detectors, while madeline undertook the development and initial testing of an mri-compatible pet insert. congratulations to both 世界杯2022赛程表淘汰赛 on their achievements!

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a paper from our group has been published titled “image quality evaluation for a clinical organ-targeted pet camera” in frontiers in oncology (volume: 14, march 2024). congratulations on the published paper!

introduction: a newly developed clinical organ-targeted positron emission tomography (pet) system (also known as radialis pet) is tested with a set of standardized and custom tests previously used to evaluate the performance of positron emission mammography (pem) systems.
methods: imaging characteristics impacting standardized uptake value (suv) and detectability of small lesions, namely spatial resolution, linearity, uniformity, and recovery coefficients, are evaluated.
results: in-plane spatial resolution was measured as 2.3 mm ± 0.1 mm, spatial accuracy was 0.1 mm, and uniformity measured with flood field and nema nu-4 phantom was 11.7% and 8.3% respectively. selected clinical images are provided as reference to the imaging capabilities under different clinical conditions such as reduced activity of 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (18f-fdg) and time-delayed acquisitions. suv measurements were performed for selected clinical acquisitions to demonstrate a capability for quantitative image assessment of different types of cancer including for invasive lobular carcinoma with comparatively low metabolic activity. quantitative imaging performance assessment with phantoms demonstrates improved contrast recovery and spill-over ratio for this pet technology when compared to other commercial organ-dedicated pet systems with similar spatial resolution. recovery coefficients were measured to be 0.21 for the 1 mm hot rod and up to 0.89 for the 5 mm hot rod of nema nu-4 image quality phantom.
discussion: demonstrated ability to accurately reconstruct activity in tumors as small as 5 mm suggests that the radialis pet technology may be well suited for emerging clinical applications such as image guided assessment of response to neoadjuvant systemic treatment (nst) in lesions smaller than 2 cm. also, our results suggest that, while spatial resolution greatly influences the partial volume effect which degrades contrast recovery, optimized count rate performance and image reconstruction workflow may improve recovery coefficients for systems with comparable spatial resolution. we emphasize that recovery coefficient should be considered as a primary performance metric when a pet system is used for accurate lesion size or radiotracer uptake assessments.

continue reading the article: https://doi.org/10.3389/fonc.2024.1268991

the post new publication: image quality evaluation for a clinical organ-targeted pet camera in frontiers in oncology appeared first on rezniklab and posted by pavlo karasyuk.

date: february 12, 2024

an article has been published, in radiology: imaging cancer, reporting results from a pilot study including newly diagnosed breast cancer patients with the low-dose positron emission mammography system developed by our collaborator, radialis. see the article here.
in addition, a commentary, titled “low-dose positron emission mammography: a novel, promising technique for breast cancer detection” has been written, which discusses findings from this study and highlights their importance. see the commentary here.

the post clinical findings using a low-dose pem system appeared first on rezniklab and posted by pavlo karasyuk.

date: november 12, 2023

we are pleased to inform you that anirudh shahi and dr. oleksandr bubon attended the 2023 ieee nuclear science symposium and medical imaging conference and room temperature semiconductor detector conference in vancouver, from november 4 – 11.

anirudh presented a poster titled “multi-angle image reconstruction method for a planar organ targeted pet detector”. dr. bubon presented a poster with the following title: “performance evaluation of a high-sensitivity organ-targeted positron emission tomography (pet) system for small lesion detection and quantitative imaging”. more information about the conference and other presentations can be found here.

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members of the summer school, including the 世界杯2022赛程表淘汰赛 , supervisors from all groups involved, and the organizers.

summer has come to an end, and it marks the completion of another successful summer research session at our lab! undergraduate 世界杯2022赛程表淘汰赛 at the lab supported multiple ongoing research efforts, in addition to leading their own assigned research projects, which listed are below for each student:

• madeline rapley: timing performance and count rate statistics of radialis pet data acquisition systems
• henry maa-hacquoil: improving edge pixel resolution for organ targeted pet camera
• elliott de benetti: optimizing breast tumor detectability and delayed imaging protocol for fdg pet using kinetic modelling
• amy stieh: photo-induced crystallization in amorphous lead oxide (a-pbo) photoconductive layers
• alexander alexandrov: investigation of x-ray photoconductivity and dark current in lead-oxide x-ray detectors

two high school 世界杯2022赛程表淘汰赛 also joined the lab this summer and worked alongside the undergraduates. kenneth shahi helped perform stress measurements on a-pbo layers and jános radó simulated different light guide designs in gate. 世界杯2022赛程表淘汰赛 also had the opportunity to contribute to research for a collaborator, radialis inc., work on publications (stay tuned for these…) and two 世界杯2022赛程表淘汰赛 also got to present their work at a conference in montréal!

aside from projects, 世界杯2022赛程表淘汰赛 from our lab and other research groups participated in the summer school of health technologies lectures which included invited speakers. these talks covered the many challenges in health technologies ranging from physics, biology, computer science, engineering, and kinesiology and broadened everyone’s knowledge about this topic. the summer school also included a tour of thunder bay regional hospital’s radiation therapy department (see picture below) and also a workshop on business development, which discussed how everyone can assess and commercialize their innovative ideas.

wishing all the best to everyone for this school year. and future 世界杯2022赛程表淘汰赛 interested in physics, medical imaging, or health technologies research, you know where to look next summer .

the post student research highlights from summer 2023 appeared first on rezniklab and posted by pavlo karasyuk.

this august, four members from our lab including dr. reznik, dr. radó, amy, and alex attended the canadian semiconductor science and technology conference in montreal.

in her oral presentation, dr. reznik described our work on lead oxide x-ray photoconductive layers for application in direction conversion medical imaging detectors, see image above. dr. radó also did an oral presentation about his work on stress in thick amorphous lead oxide (a-pbo) layers. our two fabulous trainees, amy stieh and alexander alexandrov, did poster presentations, see the images below. amy discussed photo-crystallization in a-pbo and alex talked about x-ray sensitivity of pbo photodetectors.

the post the 20th canadian semiconductor science and technology conference appeared first on rezniklab and posted by pavlo karasyuk.

date: may 10, 2023

congratulations to brandon baldassi who successfully defended his msc thesis in physics!

brandon presented his work on the design and evaluation of a clinical organ-targeted positron emission tomography camera, which has been commercialized by radialis inc. results from brandon’s thesis work have been published in two publications and presented on the 2022 ieee mic conference in milan.

good luck brandon and we wish you success in your future endeavours!

[1] evaluation of a high-sensitivity organ-targeted pet camera

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date: may 9, 2023

the summer school of health technologies 2023 began on may 9th with talks from three speakers who will supervise the participating 世界杯2022赛程表淘汰赛 . each supervisor introduced ongoing research in their lab:

-> dr. alla reznik talked about advancing x-ray and pet imaging modalities for precise imaging at low radiation doses.
-> dr. mitchell albert talked about mri imaging using hyperpolarized gas and its applications in lung and brain imaging.
-> dr. nicholas ravanelli talked about his lab’s work on monitoring human physiology under heat stresses.

the summer school will consist of lectures in health technologies, research projects, and pizza! four undergraduate 世界杯2022赛程表淘汰赛 and two high school 世界杯2022赛程表淘汰赛 from our lab will be participating in the summer school. for more information, please visit the following website.

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