a paper from our group has been published titled “image quality evaluation for a clinical organ-targeted pet camera” in frontiers in oncology (volume: 14, march 2024). congratulations on the published paper!

introduction: a newly developed clinical organ-targeted positron emission tomography (pet) system (also known as radialis pet) is tested with a set of standardized and custom tests previously used to evaluate the performance of positron emission mammography (pem) systems.
methods: imaging characteristics impacting standardized uptake value (suv) and detectability of small lesions, namely spatial resolution, linearity, uniformity, and recovery coefficients, are evaluated.
results: in-plane spatial resolution was measured as 2.3 mm ± 0.1 mm, spatial accuracy was 0.1 mm, and uniformity measured with flood field and nema nu-4 phantom was 11.7% and 8.3% respectively. selected clinical images are provided as reference to the imaging capabilities under different clinical conditions such as reduced activity of 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (18f-fdg) and time-delayed acquisitions. suv measurements were performed for selected clinical acquisitions to demonstrate a capability for quantitative image assessment of different types of cancer including for invasive lobular carcinoma with comparatively low metabolic activity. quantitative imaging performance assessment with phantoms demonstrates improved contrast recovery and spill-over ratio for this pet technology when compared to other commercial organ-dedicated pet systems with similar spatial resolution. recovery coefficients were measured to be 0.21 for the 1 mm hot rod and up to 0.89 for the 5 mm hot rod of nema nu-4 image quality phantom.
discussion: demonstrated ability to accurately reconstruct activity in tumors as small as 5 mm suggests that the radialis pet technology may be well suited for emerging clinical applications such as image guided assessment of response to neoadjuvant systemic treatment (nst) in lesions smaller than 2 cm. also, our results suggest that, while spatial resolution greatly influences the partial volume effect which degrades contrast recovery, optimized count rate performance and image reconstruction workflow may improve recovery coefficients for systems with comparable spatial resolution. we emphasize that recovery coefficient should be considered as a primary performance metric when a pet system is used for accurate lesion size or radiotracer uptake assessments.

continue reading the article: https://doi.org/10.3389/fonc.2024.1268991

the post new publication: image quality evaluation for a clinical organ-targeted pet camera in frontiers in oncology appeared first on rezniklab and posted by pavlo karasyuk.

date: may 10, 2023

congratulations to brandon baldassi who successfully defended his msc thesis in physics!

brandon presented his work on the design and evaluation of a clinical organ-targeted positron emission tomography camera, which has been commercialized by radialis inc. results from brandon’s thesis work have been published in two publications and presented on the 2022 ieee mic conference in milan.

good luck brandon and we wish you success in your future endeavours!

[1] evaluation of a high-sensitivity organ-targeted pet camera

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date: november 15, 2022

we are pleased to inform you that oleksandr grynko, brandon baldassi, and borys komarov attended the 2022 ieee nuclear science symposium and medical imaging conference and room temperature semiconductor detector conference in milan, italy, from november 5-12.

oleksandr presented an oral presentation titled “amorphous lead oxide based multilayer x-ray detector with near-theoretical sensitivity.” brandon and borys each presented posters with the respective titles: “low-dose imaging performance of a clinical organ-targeted positron emission tomography (pet) camera” and “application of gpu-based reconstruction for a clinical organ-targeted pet scanner.” more information about the conference and other presentations can be found here.

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congratulations to justin stiles and brandon baldassi as well as the other co-workers in
publishing their paper “evaluation of a high-sensitivity organ-targeted pet camera”. their
paper was published in the sensors special issue advanced materials and technologies for
radiation detectors.

abstract

the aim of this study is to evaluate the performance of the radialis organ-targeted positron
emission tomography (pet) camera with standardized tests and through assessment of clinical-
imaging results. sensitivity, count-rate performance, and spatial resolution were evaluated
according to the national electrical manufacturers association (nema) nu-4 standards, with
necessary modifications to accommodate the planar detector design. the detectability of small
objects was shown with micro hotspot phantom images. the clinical performance of the camera
was also demonstrated through breast cancer images acquired with varying injected doses of 2-
[fluorine-18]-fluoro-2-deoxy-d-glucose (18f-fdg) and qualitatively compared with sample
digital full-field mammography, magnetic resonance imaging (mri), and whole-body (wb) pet
images. micro hotspot phantom sources were visualized down to 1.35 mm-diameter rods. spatial
resolution was calculated to be 2.3 ± 0.1 mm for the in-plane resolution and 6.8 ± 0.1 mm for the
cross-plane resolution using maximum likelihood expectation maximization (mlem)
reconstruction. the system peak noise equivalent count rate was 17.8 kcps at a 18f-fdg
concentration of 10.5 kbq/ml. system scatter fraction was 24%. the overall efficiency at the
peak noise equivalent count rate was 5400 cps/mbq. the maximum axial sensitivity achieved

was 3.5%, with an average system sensitivity of 2.4%. selected results from clinical trials
demonstrate capability of imaging lesions at the chest wall and identifying false-negative x-ray
findings and false-positive mri findings, even at up to a 10-fold dose reduction in comparison
with standard 18f-fdg doses (i.e., at 37 mbq or 1 mci). the evaluation of the organ-targeted
radialis pet camera indicates that it is a promising technology for high-image-quality, low-
dose pet imaging. high-efficiency radiotracer detection also opens an opportunity to reduce
administered doses of radiopharmaceuticals and, therefore, patient exposure to radiation.

continue reading the article: https://doi.org/10.3390/s22134678

the post congratulations to justin stiles and brandon baldassi on publishing a paper in sensors appeared first on rezniklab and posted by pavlo karasyuk.

the annual summer school on medical imaging project presentation competition was held in august 2016. congratulations on getting 1st place:

participant (student): keren mayorov (on the left)
supervisor: dr. alla reznik
project title: image reconstruction for organ specific positron emission tomography

participant (student): brandon baldassi (on the right)
supervisor: dr. alla reznik
project title: characterization of cadmium zinc telluride as a material for solid state detectors in advanced computed tomography

more information about competition program can be found here.

reznik’s group wish you all the best in your future endeavors.

the post summer school on medical imaging 2016 competition winners appeared first on rezniklab and posted by pavlo karasyuk.