the fiscal year 2015 (fy15) defense appropriations act provides $247.5 million to the department of defense peer reviewed medical research program (prmrp). the vision of the prmrp is to improve the health and well-being of all military service members, veterans, and beneficiaries. the prmrp challenges the scientific and clinical communities to address one of the fy15 congressionally directed topic areas with original ideas that foster new directions in basic science and translational research; novel product development leading to improved therapeutic or diagnostic tools; synergistic, multidisciplinary research program; or clinical trials that address an immediate clinical need.
as directed by the office of the assistant secretary of defense for health affairs, the defense health agency, research, development, and acquisition (dha rda) directorate manages and executes the defense health program (dhp) research, development, test, and evaluation (rdt&e) appropriation. the executing agent for the anticipated program announcements/funding opportunities is the congressionally directed medical research programs (cdmrp).
fy15 prmrp program announcements and general application instructions are posted on grants.gov.
military relevance: relevance to the healthcare needs of the military service members, veterans, and beneficiaries is a key feature of each fy15 prmrp award mechanism.
clinical trial award – pre-application due june 18, 2015
assistant professor level or above (or equivalent)
· supports the rapid implementation of clinical trials of novel interventions with the potential to have a significant impact on patient care in the topic area(s) of interest
· proposed projects may range from small proof-of-concept trials through large-scale, definitive trials
· investigational new drug or investigational device exemption applications, if needed, should be submitted to the food and drug administration before the prmrp grants.gov application submission deadline
preproposal submission is required; application submission is by invitation only
· funding limit not defined; requested funding must be appropriate for the scope of work proposed
maximum period of performance is 5 years
discovery award – letter of intent due june 25, 2015
all investigators
· supports the exploration of a highly innovative new concept or untested theory
· not intended to support the logical progression of an already established line of questioning
· clinical trials will not be funded
reviewers will be blinded to the identity of the pi, collaborators, and their organization(s)
· maximum of $200,000 for direct costs (plus indirect costs)
maximum period of performance is 18 months
focused program award – pre-application due june 18, 2015
full professor level or above (or equivalent)
•restricted to the topic areas of acupuncture, advanced prosthetics, burn pit exposure, cardiovascular heart disease, congenital heart disease, focal segmental glomerulosclerosis, healthcare-acquired infection reduction, hepatitis b, hydrocephalus, integrative medicine, metals toxicology, mitochondrial disease, nanomaterials for bone regeneration, osteoarthritis, pathogen-inactivated dried plasma, pulmonary fibrosis, psychotropic medications, respiratory health, sleep disorders, vascular malformations, and women’s heart disease
•supports a synergistic, multidisciplinary research program of at least four distinct but complementary projects addressing an overarching goal in one of the topic areas listed directly above
•projects should work together to answer critical questions, resolve differing hypotheses, and translate laboratory findings to clinical applications
•projects may range from exploratory/hypothesis-developing through small-scale clinical trials that together will address the overarching goal/question
•research team of highly qualified, multidisciplinary project leaders should be led by a principal investigator with demonstrated success in directing large, focused projects
preproposal submission is required; application submission is by invitation only
· maximum of $10 million for total costs (includes direct and indirect costs)
· maximum period of performance is 5 years
investigator-initiated research award – pre-application due june 11/2015
assistant professor level or above
(or equivalent)
· supports research that will make an original and important contribution to the field of research or patient care in the topic area(s) of interest
· partnering principal investigator (pi) option available
· clinical trials will not be funded
preproposal submission is required; application submission is by invitation only
· maximum of $1.2 million for direct costs (plus indirect costs)
· maximum of $1.5 million for direct costs (plus indirect costs) for applications including a partnering pi option
maximum period of performance is 3 years
technology/ therapeutic development award – pre-application due june 11, 2015
assistant professor level or above
(or equivalent)
· supports the development of diagnostics or therapies that have the potential to make a strong impact on patient care in the topic area(s) of interest
· product-oriented: device, drug, clinical guidelines
· clinical trials will not be funded
preproposal submission is required; application submission is by invitation only
· maximum of $1.8 million for direct costs (plus indirect costs)
maximum period of performance is 3 years