the present study examined the effectiveness and efficacy of a novel antistigma intervention in reducing mental illness stigma, as well as the role of audience empathy as a mediator of stigma reduction following antistigma intervention. study 1 examined the effectiveness of an antistigma intervention developed through grassroots collaboration between the canadian mental health association and individuals that have experienced mental illness. this intervention was unique in that it featured a multimodal format that combined psychoeducation, live contact, and a photovoice video, which has not been examined as an antistigma intervention in the literature to date. fifty-two 世界杯2022赛程表淘汰赛 viewed the intervention and completed measures of mental illness stigma at both pre- and post-intervention. results showed that participants reported decreased mental illness stigma from pre- to post-intervention. study 2 built off of these findings to examine the efficacy of the photovoice video as a standalone online antistigma intervention. online antistigma videos have not been widely researched in the literature, despite the low-cost and dissemination benefits associated with an online video format. three hundred and three 世界杯2022赛程表淘汰赛 were randomly assigned to either the photovoice video (n = 156) or a control video (n = 147). results indicated that the photovoice video was efficacious in reducing mental illness stigma, including reduced fear, anger, perceived dangerousness, and desired social distance between pre- and post-intervention, relative to the control. in addition, 104 participants (photovoice = 56; control = 48) returned to complete follow-up measures at 1-month post-intervention. photovoice was efficacious in maintaining reduced desired social distance relative to the control, indicative of a continued willingness to interact with individuals that have a mental illness. finally, viewer empathy was found to mediate the relationship between the photovoice intervention and reduced mental illness stigma, suggesting that the photovoice video reduced mental illness stigma by eliciting empathy in the viewer. implications for the development of antistigma interventions are discussed, as well as limitations of the study and directions for future research.